Kristen J Bubb Selected Research

2- (3,4- dimethoxybenzyl)- 7- (1- (1- hydroxyethyl)- 4- phenylbutyl)- 5- methylimidazo(5,1- f)(1,2,4)triazin- 4 (3H)-one

1/2018	Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure.
8/2014	Inhibition of phosphodiesterase 2 augments cGMP and cAMP signaling to ameliorate pulmonary hypertension.

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Kristen J Bubb Research Topics

Disease

4	Pulmonary Hypertension 01/2020 - 08/2014
3	Cardiovascular Diseases (Cardiovascular Disease) 03/2022 - 08/2013
3	Hypoxia (Hypoxemia) 01/2022 - 08/2014
2	Atherosclerosis 03/2022 - 01/2019
2	Peripheral Arterial Disease 01/2021 - 01/2021
2	Ischemia 01/2021 - 01/2017
2	Heart Failure 01/2020 - 01/2018
2	Vascular Remodeling 01/2019 - 08/2014
2	Fibrosis (Cirrhosis) 01/2018 - 01/2017
2	Pulmonary Arterial Hypertension 01/2016 - 08/2014
2	Hypertension (High Blood Pressure) 08/2013 - 05/2013
1	Dyslipidemias (Dyslipidemia) 03/2022
1	Overactive Urinary Bladder (Overactive Bladder) 01/2021
1	Aortic Valve Disease 01/2021
1	Intermittent Claudication 01/2021
1	Pneumonia (Pneumonitis) 01/2020
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2019
1	Type 2 Diabetes Mellitus (MODY) 01/2019
1	Inflammation (Inflammations) 01/2019
1	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 01/2018
1	Diabetes Mellitus 04/2017
1	Infarction (Infarctions) 01/2017
1	Myocardial Infarction 01/2017
1	Ventricular Remodeling 01/2017
1	Right Ventricular Hypertrophy 08/2014
1	Stroke (Strokes) 08/2013
1	Hypotension (Low Blood Pressure) 10/2012
1	Fetal Growth Retardation (Intrauterine Growth Retardation) 08/2012

Drug/Important Bio-Agent (IBA)

2	Streptozocin (Streptozotocin)FDA Link 01/2021 - 04/2017
2	mirabegronIBA 01/2021 - 01/2021
2	Bleomycin (Blenoxane)FDA LinkGeneric 01/2020 - 08/2014
2	Biomarkers (Surrogate Marker)IBA 01/2019 - 01/2019
2	Natriuretic PeptidesIBA 01/2018 - 08/2014
2	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2018 - 08/2014
2	2- (3,4- dimethoxybenzyl)- 7- (1- (1- hydroxyethyl)- 4- phenylbutyl)- 5- methylimidazo(5,1- f)(1,2,4)triazin- 4 (3H)-oneIBA 01/2018 - 08/2014
2	Vasodilator Agents (Vasodilators)IBA 04/2017 - 05/2013
2	NitratesIBA 08/2014 - 05/2013
1	LDL CholesterolIBA 03/2022
1	Triglycerides (Triacylglycerol)IBA 03/2022
1	Lipoproteins (Lipoprotein)IBA 03/2022
1	Amino Acids FDA Link 01/2022
1	CarbohydratesIBA 01/2022
1	LipidsIBA 01/2022
1	Lipoprotein(a)IBA 01/2021
1	disodium (R,R)- 5- (2- ((2- (3- chlorophenyl)- 2- hydroxyethyl)- amino)propyl)- 1,3- benzodioxole- 2,3- dicarboxylateIBA 01/2021
1	Superoxides (Superoxide)IBA 01/2021
1	Purinergic P2X7 ReceptorsIBA 01/2020
1	Dimethyl Sulfoxide (DMSO)FDA LinkGeneric 01/2020
1	Estradiol (Delestrogen)FDA LinkGeneric 01/2019
1	Insulin (Novolin)FDA Link 01/2019
1	Insulin ReceptorIBA 01/2019
1	Testosterone (Sustanon)FDA Link 01/2019
1	C-Type Natriuretic Peptide (Peptide, C-Type Natriuretic)IBA 01/2019
1	NeuropeptidesIBA 01/2018
1	Guanylate Cyclase (Guanylyl Cyclase)IBA 01/2018
1	Transforming Growth Factor beta (TGF-beta)IBA 01/2017
1	dh404 compoundIBA 01/2017
1	salicylhydroxamic acid (SHAM)IBA 01/2017
1	bardoxolone methylIBA 01/2017
1	ZP120IBA 12/2016
1	Atrial Natriuretic Factor (ANF)IBA 08/2014
1	treprostinil FDA Link 08/2014
1	Phosphodiesterase 5 InhibitorsIBA 08/2014
1	Neprilysin (Neutral Endopeptidase)IBA 08/2014
1	Epoprostenol (Prostacyclin)FDA LinkGeneric 08/2014
1	Vasoconstrictor AgentsIBA 08/2013
1	20-hydroxy-5,8,11,14-eicosatetraenoic acidIBA 08/2013
1	Hydroxyeicosatetraenoic Acids (HETE)IBA 08/2013
1	NitritesIBA 05/2013
1	Xanthine DehydrogenaseIBA 05/2013
1	Nitrite Reductases (Nitrite Reductase)IBA 05/2013
1	Antihypertensive Agents (Antihypertensives)IBA 05/2013
1	Pharmaceutical PreparationsIBA 05/2013
1	Allopurinol (Remid)FDA LinkGeneric 05/2013
1	SpermineIBA 10/2012

Therapy/Procedure

6	Therapeutics 03/2022 - 08/2014
1	Surgical Amputation (Amputations) 01/2021
1	Ligation 08/2012